Thursday, November 3, 2011
Canine parvovirus (CPV) infection is a relatively new disease that appeared for the first time in dogs in 1978. Because of the severity of the disease and its rapid spread through the canine population, CPV has aroused a great deal of public interest. The virus that causes this disease is very similar to feline panleukopenia (feline distemper) and the two diseases are almost identical. Therefore, it has been speculated that the canine virus is a mutation of the feline virus. However, that has never been scientifically proven.
Are there different strains of canine parvovirus?
Two slightly different strains of canine parvovirus, named CPV-2a (1980) and CPV-2b (1984), are recognized. They cause the same disease and vaccines give protection against both. CPV-2b is associated with the most severe disease. A distinct type of parvovirus (CPV-1) has been found in pups with diarrhea and also in normal dogs. CPV-1 is not thought to be an important cause of disease.
How does a dog become infected with parvovirus?
The main source of the virus is from the feces of infected dogs. The virus begins to be shed just before clinical signs develop and continues for about ten days. Susceptible dogs become infected by ingesting the virus. Subsequently, the virus is carried to the intestine where it invades the intestinal wall and causes inflammation. Unlike most other viruses, CPV is stable in the environment and is resistant to the effects of heat, detergents, alcohol, and many disinfectants. A 1:30 bleach solution will destroy the infective virus. CPV has been recovered from surfaces contaminated with dog feces even after three months at room temperature. Due to its stability, the virus is easily transmitted via the hair or feet of infected dogs, contaminated shoes, clothes, and other objects or areas contaminated by infected feces. Direct contact between dogs is not required to spread the virus. Dogs that become infected with the virus and show clinical signs will usually become ill within six to ten days of the initial infection.
What are the clinical signs of parvo?
The clinical signs and symptoms of CPV disease can vary, but generally they include severe vomiting and diarrhea. The diarrhea often has a very strong smell, may contain lots of mucus and may or may not contain blood. Additionally, affected dogs often exhibit a lack of appetite, marked listlessness and depression, and fever. It is important to note that many dogs may not show every clinical sign, but vomiting and diarrhea are the most common and consistent signs; vomiting usually begins first. Parvo may affect dogs of all ages, but is most common in dogs less than one year of age. Young puppies less than five months of age are usually the most severely affected, and the most difficult to treat. Any unvaccinated puppy that has vomiting or diarrhea should be tested for CPV.
How is it diagnosed?
The clinical signs of CPV infection can mimic many other diseases that cause vomiting and diarrhea; consequently, the diagnosis of CPV is often a challenge for the veterinarian. The positive confirmation of CPV infection requires the demonstration of the virus or virus antigen in the stool, or the detection of anti-CPV antibodies in the blood serum. An in-house test performed on a stool sample is available as well. Occasionally, a dog will have parvovirus but test negative for virus in the stool. Fortunately, this is an uncommon occurrence. A tentative diagnosis is often based on the presence of a reduced white blood cell count (leukopenia) and clinical signs. If further confirmation is needed, stool or blood can be submitted to a veterinary laboratory for additional tests. The absence of a leukopenia does not mean that the dog does not have CPV infection. Some dogs that become clinically ill may not have a low white blood cell count.
Can parvo be treated successfully?
There is no treatment to kill the virus once it infects the dog. However, the virus does not directly cause death; rather, it causes loss of the lining of the intestinal tract, and destroys some blood cell elements. The intestinal damage results in severe dehydration (water loss), electrolyte (sodium and potassium) imbalances, and infection in the bloodstream (septicemia). When the bacteria that normally live in the intestinal tract are able to get into the blood stream, it becomes more likely that the animal will die. The first step in treatment is to correct dehydration and electrolyte imbalances. This requires the administration of intravenous fluids containing electrolytes. Antibiotics and anti-inflammatory drugs are given to prevent or control septicemia. Antispasmodic drugs are used to inhibit the diarrhea and vomiting that perpetuate the problems.
What is the survival rate?
Most dogs with CPV infection recover if aggressive treatment is used and if therapy is begun before severe septicemia and dehydration occur. For reasons not fully understood, some breeds, notably the Rottweiler, Doberman pinscher and English springer spaniel, have a much higher fatality rate than other breeds.
Can parvo be prevented?
The best method of protecting your dog against CPV infection is proper vaccination. Puppies receive a parvo vaccination as part of their multiple-agent vaccine given at 8, 12, and 16 weeks of age. In some situations, veterinarians may give the vaccine at two-week intervals with an additional booster at 18 to 22 weeks of age. After the initial series of vaccinations, all dogs should be given a booster vaccination at one year. Thereafter your veterinarian will discuss with you an appropriate schedule of revaccination. Adult dogs considered to be at low risk for contracting the disease may be vaccinated every two to three years. Your veterinarian and you should make the final decision about the vaccination schedule that best fits your pet’s lifestyle.
Is there a way to kill the virus in the environment?
The stability of the CPV in the environment makes it important to properly disinfect contaminated areas. This is best accomplished by cleaning food bowls, water bowls, and other contaminated items with a solution of 1/2 cup of chlorine bleach in one gallon of water (133 ml in 4 liters of water). It is important that chlorine bleach be used because most disinfectants, even those claiming to be effective against viruses, will not kill the canine parvovirus.
Does parvovirus pose a health risk for me? How about for my cats?
It is important to note that there is no evidence to indicate that CPV is transmissible to cats or humans.
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